Short-term memory loss. -Chronic treatment should be done with an oral preparation in patients with normal intestinal absorption. Before I quit drinking, I had extremely low energy levels, tingling sensations in my limbs, and symptoms of an inflamed liver. Epub 2019 Dec 11. This article addresses the importance of maintaining adequate vitamin B12 levels and outlines the benefits and risks associated with vitamin B12 shots. Accessibility When this occurs, the cells of the stomach cannot do their job of making and secreting a substance called intrinsic factor, which enhances B-12's absorption. Treating vitamin B12 or folate deficiency anaemia Most cases of vitamin B12 and folate deficiency can be easily treated with injections or tablets to replace the missing vitamins. Thanks for motivating others here and keep it up! Some of the signs of lower B12 levels in your body include: Treatment of vitamin B12 deficiency often includes dietary changes, B12 shots, or supplements. b12 therapy for macrocytosis ineffective. Most people enjoy drinking alcohol, but even moderate amounts of alcohol consumption can have negative effects on the amount of vitamin B-12 you absorb. Ive never had a bad reaction to vitamins or natural supplements. information is beneficial, we may combine your email and website usage information with Studies show that even a little amount of alcohol can decrease vitamin B12 absorption by about 5-6%. Therefore, high blood serum levels for vitamin B12 can actually be a marker of liver disease, rather than a sign that the body overall contains optimal levels of vitamin B12. Tell your doctor about all your current medicines and any medicine you start or stop using. For these, please consult a doctor (virtually or in person). You might also face a higher risk of other deficiencies, including folate, of vitamin B-9. What should I avoid while using Vitamin B12 injection? Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, a causal relationship has not been established, and the mechanisms mediating this association are speculative. J Am Diet Assoc. People who are 60 years old or older are more likely to have vitamin B12 deficiency compared to other age groups. What is the purpose of a vitamin B-12 level test? What Is the Best Non-Surgical Treatment for Wrinkles? Large amounts of alcohol irritate the mucosal linings in the stomach and intestines leading to a condition called gastritis which further leads to reduced absorption of B12 levels in the body. Vitamin B 12 deficiency affects multiple systems, . Your child's dose will depend on age, weight, diet, and other factors. thank god I have support and unconditional love in my life. If you have a very low level of B12, you may need more shots in the beginning. Vitamin B12 can improve your mood during weight loss programs. Related conditions. Low levels of a vitamin can result from eating a poor diet or not being able to absorb . Vitamin B12 (Cyanocobalamin Injection) - Side Effects, Interactions Sandoval C, Faras J, Zamorano M, Herrera C. Antioxidants (Basel). Depending on the cause of the deficiency, the person may only have to be treated until their vitamin B12 levels are back to normal, or they may have to take vitamin B12 therapy for the rest of their life. Folic acid alone will not treat Vitamin B12 deficiency or prevent possible damage to the spinal cord. Older adults and people with digestive tract conditions that affect absorption of nutrients also are susceptible to vitamin B-12 deficiency. This build-up can lead to severe megaloblastic anemia and some other health conditions. And, of course, if you're not eating a balanced diet, you could miss out on other nutrients crucial for good health, including vitamin C, protein, dietary fiber and more. Fairfield KM. Acne Scar Reduction What Is the Best Treatment? Situations or conditions that can cause vitamin B12 deficiency include: Vitamin B12 deficiency can cause physical, neurological and psychological symptoms. Am J Clin Nutr. Vitamin B12 intramuscular injections (a shot that goes into the muscle). To provide you with the most relevant and helpful information, and understand which Vitamin B12 may cause serious side effects. Long-term low vitamin B12 levels caused by pernicious anemia can affect your nervous system. Usual Adult Dose for B12 Nutritional Deficiency: 1000 mcg intramuscularly is the flushing dose. Tell your doctor if you are pregnant or breastfeeding. Your child's dose will depend on age, weight, diet, and other factors. More severe side effects of vitamin B12 deficiency include: Peripheral neuropathy. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. The trick with supplements is to find the right balance between your B12 injections and the supplements. Alcohol abuse: Patients older than 75 years . no alcohol, B12 injections intramuscular or subcutaneous. The content on fitrecovery.com is designed to support, not replace, medical or psychiatric treatment. Habitual alcohol consumption can affect levels of the B-12 vitamin in a number of ways. National Library of Medicine When there is reduced consumption of B12 vitamins along with its depletion due to alcohol, it can lead to various health conditions. (2020). General physical symptoms of vitamin B12 deficiency can include: Neurological symptoms of vitamin B12 deficiency can include: Psychological symptoms of vitamin B12 deficiency can include: It can be difficult to diagnose vitamin B12 deficiency because symptoms are not always present or the symptoms can be similar to other nutritional deficiencies. I started having fainting spells earlier this summer. If a person has low vitamin B12 levels due to a health condition, a doctor may recommend oral supplementation or injections of the vitamin. no drugs/alcohol. By using our website, you consent to our use of cookies. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. | Benefits of MIC injections, All You Need to Know About Laser Hair Removal. Here are the percentages of people who have vitamin B12 deficiency based on age ranges: Vitamin B12 deficiency happens if you are not eating enough vitamin B12 or your body is not absorbing the vitamin B12 you consume properly. 2020 Jul 7;12(7):2014. doi: 10.3390/nu12072014. Vitamin B12 may interact with certain medications. Get useful, helpful and relevant health + wellness information. Ankar A, Kumar A. Vitamin B12 deficiency. Vitamin B-12 deficiency is not common in the U.S. Thank you. Vitamin B12 side effects. Your Free Challenge gave me more useful info than any paid course Ive ever taken. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Get your prescription refilled before you run out of medicine completely. Vitamin B12 deficiency is also commonly linked with depression. Call your doctor at once if you have: heart problems--swelling, rapid weight gain, feeling short of breath; fluid build-up in or around the lungs-- pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold and clammy skin, anxiety . Please enable it to take advantage of the complete set of features! The best ones have worked so well that theyve seriouslychanged my life. Vitamin B12 helps in the production of brain chemicals and also helps with some crucial brain functions. An older study indicated that moderate alcohol intake diminished vitamin B12 by 5% among "healthy,. Alcohol's Effects on B-12 Absorption | livestrong for weight loss. Consider coenzyme q Thyroid and Folic Acid should be assayed. Vitamin B12 is actually necessary for a large number of bodily processes, including: Because alcohol consumption markedly depletes vitamin B12 levels, doctors often recommend that alcoholics take supplements containing the full range of B vitamins. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The simple answer to this question is yes. Vitamin B12 deficiency anemia happens when your body does not have enough healthy red blood cells because your body has a vitamin B12 deficiency. Two common types of GERD medicines have been associated with B-12 deficiency to varying degrees: H-2-receptor blockers. They have no major side effects. Oral contraceptives did not affect biochemical folate indexes and homocysteine concentrations in adolescent females. Moderate-to-severe chronic alcohol consumption can have damaging effects on your stomach lining, causing a condition called atrophic gastritis, or inflammation of the stomach. Not all substances necessary for human metabolism can be absorbed effectively by injection; B-12 is an anomaly. People must always inform a doctor about all prescription and over-the-counter drugs they are taking before receiving a vitamin B12 shot. Some peoples bodies do not produce enough stomach acid or intrinsic factor if they have a condition known as autoimmune atrophic gastritis. Sun & Tue - Closed, 2081 Forest Ave, Suite 1, San Jose, CA 95128. Vitamin B12 deficiency happens when your body is either not getting enough or not absorbing enough vitamin B12 from the food that you eat that it needs to function properly. Many people have found Calm Support and Sleep Support to be an extremely powerful combination for combatting cravings, getting their energy levels back, and sleeping better after quitting drinking. Heartburn medicines and B-12 deficiency - Mayo Clinic Uses Before taking Warnings Side effects Overdose Dosage Uses of Cyanocobalamin Injection: It is used to help with some kinds of anemia. It is toxic to the liver and the brain. Keep it out of the reach of children and pets. Ast is normal at 23, alt slightly elevated at 42, b12 at 1183, folate and others normal. It is illegal for you to drink alcohol at your age. We do not endorse non-Cleveland Clinic products or services. Youre very welcome Daniel, glad you enjoyed it! Tell any doctor who treats you that you are using Vitamin B12. Alcohol affects B12 absorption in the body in many ways. Vitamin B12 shots may not be suitable for people with a history of: Most people get enough vitamin B12 from their diet, but some people have a deficiency. Cocktails at night almost every night, and maybe once a month Ill drink through an entire day on the weekend, booze and snooze, which became Im going to Boise cause humor softens most everything. Common side effects of Vitamin B12 may include: This is not a complete list of side effects and others may occur. Brand names: Vitamin B12, Vitamin B-12 Conclusions: Vitamin B12 is present in many dietary sources, such as: In animal-based foods, vitamin B12 binds to the protein molecules. Multivitamins Containing No Vitamin A or E, Vitamin B12 Injections & Alcohol Ingestion, Difference Between Vitamin B-12 & Folic Acid, International Journal of Cancer; Alcohol Consumption and Chronic Atrophic Gastritis: Population-Based Study Among 9,444 Older Adults from Germany; Lei Gao et al, Harvard Health Publishing: Vitamin B12 deficiency can be sneaky, harmful. Consumption of alcohol (of any kind) affects the level of B12 absorption in the body even if taken in moderate amounts. They are the absolute Fit I needed because they are so diversified in what tolls work for you. Some have simply worked much better than others. Call your doctor for medical advice about side effects. Learn more here about vitamin B12, Many vitamin B-12 supplements contain much more of the vitamin than the body needs. Generic name: cyanocobalamin (injection) [sye-AN-oh-koe-BAL-a-min] Vitamin B12 Injection | Cleveland Clinic In severe alcoholism, the majority of the diet is replaced by alcohol, resulting in . Your dose needs may change if you become pregnant, if you breastfeed, or if you eat a vegetarian diet. Background: Knowing how alcohol affects B12 absorption might help you make an informed decision about your drinking habit. Cyanocobalamin (B12) Injection Generic name: Cyanocobalamin (B12) Injection [ sye-an-oh-koe-BAL-a-min ] Brand name: Cobal 1000 Drug class: Vitamins Medically reviewed by Drugs.com. Design: 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Tell your doctor if you are pregnant or breastfeeding. Although alcohol is considered to be an appetite stimulant, too much alcohol can have a negative effect on your diet. Degeneration of the spinal cord. This glaring omission causes an incredible amount of preventable suffering. If you are a Mayo Clinic patient, this could any ideas? Blood collected at baseline and week 8 of each treatment period was analyzed for serum folate, vitamin B(12), homocysteine (HCY), and methylmalonic acid (MMA) concentrations. How to Take Care of Your Face After Fillers? Studies show that even a little amount of alcohol can decrease vitamin B12 absorption by about 5-6%. Can poor sleep impact your weight loss goals? Unable to load your collection due to an error, Unable to load your delegates due to an error. low potassium level - leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling. It's found naturally in many foods, such as meat, fish and dairy products. Vitamin B12 is needed to make red blood cells. This can lead to permanent and severe neurological issues. Vitamin B12 is a man-made form of vitamin B12. (https://www.aafp.org/afp/2017/0915/p384.html), (https://ods.od.nih.gov/factsheets/VitaminB12-Consumer/). Hydroxocobalamin: a medicine to treat vitamin B12 deficiency Medically reviewed by Drugs.com on Nov 28, 2022. What is the latest research on the form of cancer Jimmy Carter has? Vitamin B12 foods: What to eat and avoid - Medical News Today Vitamin B12 deficiency can be treated with vitamin B12. Use Vitamin B12 exactly as prescribed by your doctor. We avoid using tertiary references. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. Options for vitamin B12 treatment include: A person is more likely to develop vitamin B12 deficiency if they have one or more of the following risk factors: Most people can prevent vitamin B12 deficiency by consuming foods and drinks that have vitamin B12. Abdollahi Z, Elmadfa I, Djazayeri A, Sadeghian S, Freisling H, Mazandarani FS, Mohamed K. Ann Nutr Metab. This is because shots enable the body to absorb vitamin B12 without it having to go through the digestive system. Get FREE daily coaching messages from Chris Scott to help you quit or cut down on alcohol in just 10 days! You may report side effects to FDA at 1-800-FDA-1088. Vitamin b12 injection needle size. Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years. Vitamin B-12 and other B vitamins play a role in producing brain chemicals that affect mood and other brain functions. Over half of those who were vegan and 7% of those who were vegetarian had low vitamin B12 levels, compared with under 1% of people who ate meat. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. 1998 Jan;98(1):49-55. doi: 10.1016/S0002-8223(98)00014-5. Vitamin B12 Injection: Side Effects, Uses & Dosage - Drugs.com Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Causes and pathophysiology of vitamin B12 and folate deficiencies. Alcohol may act through altered status of folate and vitamin B(12), two vitamins required for DNA methylation and nucleotide synthesis, and thus cell integrity. If I were to quit drinking today, I would take two supplements that contain large doses of vitamin B12: Vitamin B12 is just the tip of the iceberg with these supplements. High h&h, high mcv, low mchc, low rdw, neutropenia, & lymphocytosis all values recurring for a few years. Vitamin B12 Injections & Alcohol Ingestion | livestrong Vitamin B12 test: This tests for the levels of vitamin B12 in a person's blood. If dietary sources are insufficient, however, a doctor may recommend supplementation through pills or injections, depending on the cause of the deficiency. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. When I quit drinking, I was deficient in many vitamins and minerals despite being an otherwise active man in my twenties. An increase in homocysteine is associated with an increased risk of heart attack and stroke. Reduced levels of B12 vitamin can induce mood changes. If you have already been diagnosed with vitamin B12 deficiency and are experiencing new or concerning symptoms, be sure to reach out to your healthcare provider. The https:// ensures that you are connecting to the I find alcohol has a much stronger effect since my B12 has been low. The site is secure. The goal of treatment is to increase your vitamin B12 level. Vitamin B12: Fact sheet for professionals. As chronic alcohol consumption progressively damages this organ, vitamin B12 stores in the liver become even more severely depleted. information submitted for this request. Why Is Mesotherapy Treatment Used for Hair Fall Problems? Examples include omeprazole, esomeprazole and lansoprazole. If the infant is entirely breastfed, they may not consume enough vitamin B12. It is possible you may need shots every month for the rest of your life. Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Cyanocobalamin (B12) Injection Information - Drugs.com Does Drinking Alcohol Affect Vitamin B12 Levels? - RANI V.RAMACHANDRAN M.D. Your body does not make vitamin B12 on its own, so you have to consume food and drinks that have vitamin B12 in order to get it. https://www.uptodate.com/contents/search. Because of this, a lack of vitamin B12 can cause anemia. Use the medicine exactly as directed. A reticulocyte count is also in order as new-made reds can be quite large. Get FREE daily coaching messages from Chris Scott to help you quit or cut down on alcohol in just 10 days. Two types of vitamin B12 injections are usually given - hydroxocobalamin and cyanocobalamin. Do not stop using the medicine unless your doctor tells you to. Available for Android and iOS devices. Review/update the B-12 shots: Do they work for weight loss? - Mayo Clinic I send out an email most Fridays, so be sure to check your inbox next Friday! Started slowly. Anyone who has signs and symptoms of a vitamin B12 deficiency or pernicious anemia should consult a doctor. https://www.micromedexsolutions.com. Many people get vitamin B12 shots, or take oral capsules, to maintain a sense of well-being and high energy. Maintenance dose: 100 to 1000 mcg monthly Written by Cerner Multum. The study design was a randomized, diet-controlled crossover intervention. B12 injections and alcohol | HealthTap Online Doctor Vitamin B12 And Alcohol - Nutrient Deficiency And Repair information and will only use or disclose that information as set forth in our notice of Avoid drinking large amounts of alcohol while you are being treated with Vitamin B12 injection. Nascobal, Neuroforte-R, CaloMist, Cobal 1000, +4 more. However, since most alcohol-dependent people already have poor gut health, it is difficult for them to absorb enough vitamin B12 from foods alone. Absorption of B12 vitamins is connected to the consumption of alcohol and vitamin B12 deficiency can lead to health conditions. I never took a standalone B12 supplement, but I took various B-complexes bought from supermarkets after I quit drinking. Epub 2008 Nov 10. i'm on vitamin b12. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Cardiovascular health: Insomnia linked to greater risk of heart attack. Facts & Comparisons eAnswers. Vitamin B12 is an important vitamin that your body needs to be healthy. Rani MD is a skin care clinic in San Jose and we offer a variety of aesthetic treatments starting fromPRP treatmentto MIC injections. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, 20202025 Dietary Guidelines for Americans, https://www.ncbi.nlm.nih.gov/books/NBK441923/, https://rarediseases.info.nih.gov/diseases/10310/autoimmune-atrophic-gastritis, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933506/, http://lpi.oregonstate.edu/mic/vitamins/vitamin-B12, https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=579bd1fe-51a1-403f-a422-0fb701aab57d, https://www.sciencedirect.com/topics/food-science/recommended-dietary-allowance, https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494183/, https://pubmed.ncbi.nlm.nih.gov/25756278/. Low levels of B-12 and other B vitamins such as vitamin B-6 and folate may be linked to depression. (did drink alcohol 4 days prior to blood work, but typically drink once a week). Any person can develop vitamin B12 deficiency at any age. Im tall but light. -100 mcg every 3 to 4 days for 2 to 3 weeks, then: Had 2 glasses of wine after b12 injec - Pernicious Anaemi Consider getting your heart checked out, possibly by 2d echo. COMMON BRAND NAME (S): B-12 Compliance Kit, B-12 Injection Kit, Cyomin, Dodex, LA-12, Nutri-Twelve, Physicians EZ Use B-12 . Gastritis reduces the production of hydrochloric acid which leads to the growth of intestinal bacteria. Follow state or local laws about how to dispose of this container. Call your doctor at once if you have: heart problems--swelling, rapid weight gain, feeling short of breath; fluid build-up in or around the lungs--pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold and clammy skin, anxiety, rapid heartbeats; or. A doctor may recommend vitamin B12 shots for people who are at risk of a deficiency or its complications. Vitamin B-12 and depression: Are they related? - Mayo Clinic A 5 oclock beer on s three beer day turned into a 4 oclock 4 beer day Etc etc Then starting near (or just before) noon with 5 to 6 beers being regular. . Eur J Nutr. Advertising on our site helps support our mission. doi: 10.3945/ajcn.111.013300. Last reviewed by a Cleveland Clinic medical professional on 04/25/2022. Duration of therapy: Life Vitamin B12 - Health Professional Fact Sheet Pernicious Anemia: Definition, Symptoms, Causes & Treatment Alcohol does not affect how this medicine works. Effects of moderate alcohol consumption on folate and vitamin B(12 Am J Clin Nutr. Chris Scott founded Fit Recovery in 2014 to help people from around the world dominate alcohol dependence and rebuild their lives from scratch. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Folate and vitamin B-12 biomarkers in NHANES: history of their measurement and use. There's no solid proof that vitamin B-12 shots, also called injections, help you lose weight. Are you a social drinker? Dorgan JF, Jung S, Dallal CM, Zhan M, Stennett CA, Zhang Y, Eckert RL, Snetselaar LG, Van Horn L. Cancer Causes Control. https://www.aafp.org/afp/2017/0915/p384.html. Drug class: Vitamins. Vitamin B-12 injections are often given to those who ingest alcohol on a consistent basis, because chronic alcohol exposure is a precursor for significant deficiency. Vitamin B12 shots are only available by prescription following a clinical diagnosis of low levels. Thanks! Top answers from doctors based on your search: Created for people with ongoing healthcare needs but benefits everyone. Vitamin B12, also known as cobalamin, is a water soluble vitamin that is most often associated with energy levels. Habitual alcohol consumption can affect levels of the B-12 vitamin in a number of ways. People can have a vitamin B12 deficiency without having anemia. If you're taking hydroxocobalamin, keep the following things in mind: Although this injection takes effect right away, it may take some days or even a few weeks for . HealthUnlocked: vitamin B12 forum healthunlocked.com. Tell any doctor who treats you that you are using Vitamin B12 injection. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Would you like email updates of new search results? Depression. The 20202025 Dietary Guidelines for Americans recommend meeting the need for vitamin B12 and other nutrients through diet first and foremost. Between them, they contain a lot of powerful nutrients for biochemical repair. Or are you a person who likes to finish your day with a small drink? Copyright www.ranimd.com. Accessed Jan. 9, 2021. What sort of risk of endocarditis few yrs after mitral repair when having 6 b12 loading doses in 2 weeks and B-12 is necessary for many biological functions, including the maintenance of blood and neural cells. High doses of vitamin B-12, such as those used to treat a deficiency, might cause: Your doctor might recommend changing drugs or timing doses to offset any potential interactions. Symptoms of potential nervous system problems include: Confusion. . Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Vitamin B12. In severe alcoholism, the majority of the diet is replaced by alcohol, resulting in serious malnutrition, with one of the most serious concerns being lack of B-12 in your system. Low stomach acid also enables certain bacteria to grow, and these can use up vitamin B12 stores. Tell your doctor about any changes in your diet or medical condition. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Food sources of vitamin B-12 include poultry, meat, fish and dairy products. If you have risk factors for developing vitamin B12 deficiency or are experiencing symptoms, be sure to contact your doctor to get a blood test to check your levels. Suffer To Tougher, The Ups & Downs of Alcohol Recovery Ft. JohnnyO, Hyperbolic Discounting: The Invisible Force Preventing Addiction Recovery, GABA and Alcohol: GABA Supplement for Alcohol Withdrawal, Kudzu Recovery For Alcoholics: How It Works, All About DLPA For Addiction, Depression, PAIN & More, Quitting Alcohol Timeline and Body Repair After Quitting Drinking, Moderate drinking among healthy, middle aged women produced a statistically significant reduction in blood serum levels of vitamin B12 (, Supplementation in healthy women over 60 with vitamin B12 and other B-vitamins over 6 months reversed these nutrient deficiencies and decreased levels of homocysteine, a compound associated with cardiovascular disease (, Alcohol consumption in healthy male volunteers reduces B vitamin concentration, including vitamin B12, and raises levels of inflammatory compounds (, In severe alcoholics with liver disease, levels of vitamin B12 in the blood increase as the injured liver fails to hold on to stores of this vitamin (, Falsely high serum levels of vitamin B12 can be caused by alcoholic liver disease (.